Iprindole
Title: Iprindole
CAS Registry Number: 5560-72-5
CAS Name: 6,7,8,9,10,11-Hexahydro-N,N-dimethyl-5H-cyclooct[b]indole-5-propanamine
Additional Names: 5-[3-(dimethylamino)propyl]-6,7,8,9,10,11-hexahydro-5H-cyclooct[b]indole; 1-(3-dimethylaminopropyl)-2,3-hexamethyleneindole; pramindole (obsolete)
Trademarks: Tertran (Wyeth)
Molecular Formula: C19H28N2
Molecular Weight: 284.44
Percent Composition: C 80.23%, H 9.92%, N 9.85%
Literature References: Prepn: L. M. Rice, M. E. Freed, BE 623933; eidem, US 3282942 (1963, 1966, both to Am. Home Prods.); Rice et al., J. Med. Chem. 7, 313 (1964). Pharmacology: Gluckman, Baum, Psychopharmacologia 15, 169 (1969); Baum et al., Eur. J. Pharmacol. 13, 287 (1971). Mechanism of action: Miller et al., Experientia 26, 863 (1970); Lemberger et al., Biochem. Pharmacol. 19, 3021 (1970). Freeman, Sulser, J. Pharmacol. Exp. Ther. 183, 307 (1972).
 
Derivative Type: Hydrochloride
CAS Registry Number: 20432-64-8
Manufacturers' Codes: Wy-3263
Trademarks: Prondol (Wyeth); Galatur (Wyeth)
Molecular Formula: C19H28N2.HCl
Molecular Weight: 320.90
Percent Composition: C 71.11%, H 9.11%, N 8.73%, Cl 11.05%
Properties: Crystals from methanol + acetone, mp 146-147°.
Melting point: mp 146-147°
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.

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