Isoladol
Title: Isoladol
CAS Registry Number: 530-34-7
CAS Name: b-Amino-4-methoxy-a-(4-methoxyphenyl)benzeneethanol
Additional Names: 2-amino-1,2-bis(p-methoxyphenyl)ethanol; isodianisylethanolamine; di-p-methoxyphenylhydroxyethylamine
Trademarks: Evadol (Clin-Comar-Byla)
Molecular Formula: C16H19NO3
Molecular Weight: 273.33
Percent Composition: C 70.31%, H 7.01%, N 5.12%, O 17.56%
Literature References: Prepd by the condensation of anisaldehyde and glycine: Read, Campbell, J. Chem. Soc. 1930, 2676; Lespagnol, Pharmacie Chimique (Paris, 3rd ed., 1950) p 695.
 
Derivative Type: dl-Form
Properties: Glistening prisms from alcohol, mp 135.5°. Sol in ethyl acetate.
Melting point: mp 135.5°
 
Derivative Type: dl-Form hydrochloride
Manufacturers' Codes: LC-2
Trademarks: Evaclin
Properties: Crystals, dec about 200°. Sol in water.
 
Derivative Type: l-Form
Properties: Needles from abs alcohol, mp 111-112°. [a]D20 -150° (c = 0.952 in abs alcohol).
Melting point: mp 111-112°
Optical Rotation: [a]D20 -150° (c = 0.952 in abs alcohol)
 
Derivative Type: l-Form hydrochloride
Properties: Crystals from ethyl acetate, dec 188-190°. [a]D20 -99.0° (c = 0.5805). Sol in water.
Optical Rotation: [a]D20 -99.0° (c = 0.5805)
 
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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