Lochnericine
Title: Lochnericine
CAS Registry Number: 72058-36-7
CAS Name: (5a,6a,7a,12b,19a)-2,3-Didehydro-6,7-epoxyaspidospermidine-3-carboxylic acid methyl ester
Molecular Formula: C21H24N2O3
Molecular Weight: 352.43
Percent Composition: C 71.57%, H 6.86%, N 7.95%, O 13.62%
Literature References: Indole alkaloid. From Vinca rosea Linn. (Catharanthus roseus G. Don.), Apocynaceae: Gorman et al., J. Am. Pharm. Assoc. 48, 256 (1959); Svoboda et al., ibid. 48, 659 (1959); Moza, Trojánek, Collect. Czech. Chem. Commun. 28, 1419 (1963). Structure: Moza et al., Tetrahedron Lett. 1964, 2561.
Properties: Crystals from methanol, dec 190-193°. [a]D27 -432° (chloroform). pKa in 66% DMF: 4.2. uv max (ethanol): 227, 299, 328 nm (log e 4.10, 4.15, 4.32).
pKa: pKa in 66% DMF: 4.2
Optical Rotation: [a]D27 -432° (chloroform)
Absorption maximum: uv max (ethanol): 227, 299, 328 nm (log e 4.10, 4.15, 4.32)

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