Mechlorethamine Oxide Hydrochloride
Title: Mechlorethamine Oxide Hydrochloride
CAS Registry Number: 302-70-5
CAS Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanamine N-oxide hydrochloride
Additional Names: 2,2¢-dichloro-N-methyldiethylamine N-oxide hydrochloride; N-methyl-2,2¢-dichlorodiethylamine N-oxide hydrochloride; methylbis(b-chloroethyl)amine N-oxide hydrochloride; methyldi(2-chloroethyl)amine N-oxide hydrochloride
Trademarks: Nitromin; Mitomen; Mustron
Molecular Formula: C5H12Cl3NO
Molecular Weight: 208.51
Percent Composition: C 28.80%, H 5.80%, Cl 51.01%, N 6.72%, O 7.67%
Literature References: Prepd by treating 2,2¢-dichloro-N-methyldiethylamine with hydrogen peroxide and acetic anhydride in ether, followed by shaking with 10% hydrochloric acid: Aiko et al., J. Pharm. Soc. Jpn. 72, 1297 (1952, English Text), C.A. 47, 1289 (1953). Cf. Stahmann, Bergmann, J. Org. Chem. 11, 586 (1946).
Properties: Prisms from acetone, mp 109-110°. Sol in water.
Melting point: mp 109-110°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards.

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