Mepitiostane
Title: Mepitiostane
CAS Registry Number: 21362-69-6
CAS Name: (2a,3a,5a,17b)-2,3-Epithio-17-[(1-methoxycyclopentyl)oxy]androstane
Additional Names: cyclopentanone 2a,3a-epithio-5a-androstan-17b-yl methyl acetal
Manufacturers' Codes: 10364-S
Trademarks: Thiodelone (Shionogi); Thioderon (Shionogi)
Molecular Formula: C25H40O2S
Molecular Weight: 404.65
Percent Composition: C 74.20%, H 9.96%, O 7.91%, S 7.92%
Literature References: Orally active deriv of epitiostanol, q.v. Prepn: T. Komeno, ZA 6800565 corresp to US 3567713 (1968, 1971 both to Shionogi); T. Komeno et al., Shionogi Kenkyushu Nempo 19, 3 (1969), C.A. 72, 28554u (1970). Inhibitory effect on mammary tumors in rats: O. Takatani, S. Kumaoka, Gann 68, 337 (1977), C.A. 87, 112187u (1977). Clinical study in advanced breast cancer: K. Inoue et al., Cancer Treat. Rep. 62, 743 (1978). Toxicity studies: Oyo Yakuri 16, 739-812 (1978), C.A. 90, 146152f, 146153g (1979).
Properties: Cryst, mp 98-101°. [a]D20 +22.5 ±0.5° (c = 1 in chloroform).
Melting point: mp 98-101°
Optical Rotation: [a]D20 +22.5 ±0.5° (c = 1 in chloroform)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Hormonal); Androgens.

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