Micrococcin P
Title: Micrococcin P
CAS Registry Number: 1392-46-7
Additional Names: Micrococcin
Literature References: Antibiotic substance produced by a species of Micrococcus: cf. Br. J. Exp. Pathol. 29, 473 (1948). Isoln of micrococcin P from B. pumilus: Heatley, Doery, Biochem. J. 50, 247 (1951). Probable identity of micrococcin and micrococcin P: Abraham et al., Nature 178, 44 (1956). Structure studies: Brookes et al., J. Chem. Soc. 1957, 689; Brookes et al., ibid. 1960, 916; Dean et al., ibid. 1961, 3394; James, Watson, ibid. C, 1966, 1361. The antibiotic is a mixture of two components, P1 (major) and P2. Proposed total structure of P1: J. Walker et al., Chem. Commun. 1977, 706. Revised structure of P1 and structure of P2: B. W. Bycroft, M. S. Gowland, ibid. 1978, 256. Mechanism of action: E. Cundliffe, J. Thompson, Eur. J. Biochem. 118, 47 (1981). Review: Pestka in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 480-486.
Properties: Needles from ethanol, dec 222-228°. [a]D21 +116° (c = 0.10 in 90% ethanol). uv max (ethanol): 345 nm. Sol in ethanol, chloroform, acetone, glacial acetic acid, pyridine. Insol in ether, benzene, amyl acetate, glycerol. Very slightly sol in water.
Optical Rotation: [a]D21 +116° (c = 0.10 in 90% ethanol)
Absorption maximum: uv max (ethanol): 345 nm

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