Miloxacin
Title: Miloxacin
CAS Registry Number: 37065-29-5
CAS Name: 5,8-Dihydro-5-methoxy-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
Additional Names: 6,7-methylenedioxy-1-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; antibiotic AB 206
Manufacturers' Codes: AB-206
Trademarks: Fuldazin (Sumitomo)
Molecular Formula: C12H9NO6
Molecular Weight: 263.20
Percent Composition: C 54.76%, H 3.45%, N 5.32%, O 36.47%
Literature References: Quinolone antibacterial; analog of oxolinic acid, q.v. Prepn: T. Nakagome et al., DE 2134451; eidem, US 3799930 (1972, 1974 both to Sumitomo). Mode of action: T. Nagate et al., Antimicrob. Agents Chemother. 17, 763 (1980). Series of articles on antibacterial activity, absorption and excretion in animals, determn of metabolites by HPLC: ibid. 18, 37-49 (1980). Reproduction studies in rats: T. Yamada et al., Oyo Yakuri 19, 651, 815, 833 (1980), C.A. 93, 197897x, 215570s, 215571t (1980).
Properties: Colorless prisms from DMF, mp 264° (dec).
Melting point: mp 264° (dec)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.

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