Nimorazole
Title: Nimorazole
CAS Registry Number: 6506-37-2
CAS Name: 4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine
Additional Names: N-2-morpholinoethyl-5-nitroimidazole; 1-(2-N-morpholinylethyl)-5-nitroimidazole; nitrimidazine
Manufacturers' Codes: K-1900
Trademarks: Esclama (Montedison); Naxofem (Farmitalia); Naxogin (Erba)
Molecular Formula: C9H14N4O3
Molecular Weight: 226.23
Percent Composition: C 47.78%, H 6.24%, N 24.77%, O 21.22%
Literature References: Prepn: BE 667262; Giraldi, Mariotti, US 3399193 (1965, 1968 both to Carlo Erba); NL 6609552; NL 6609553; Gal and Carlson et al., US 3458528 and US 3646027 (1967, 1967, 1969, 1972, all to Merck & Co.). Synthesis and biological activity studies: Giraldi et al., Arzneim.-Forsch. 20, 52 (1970). Pharmacology and toxicology: de Carneri et al., Progr. Antimicrob. Anticancer Chemother., Proc. 6th Int. Congr. Chemother. vol. I, Tokyo, 1969 (Univ. of Tokyo Press, 1970, Tokyo) pp 149-154. Clinical results: Emanueli, de Carneri, ibid. vol. II, pp 369-372; Evans, Catterall, Br. Med. J. IV, 146 (1971). Metabolic studies: Giraldi, Biochem. Pharmacol. 20, 339 (1971). Acute toxicity data: B. Cavalleri et al., J. Med. Chem. 21, 781 (1978).
Properties: Crystals from water, mp 110-111°. Slightly sol in water at room temp; sol in alcohols, acetone, chloroform. LD50 orally in mice: 1530 mg/kg (Cavalleri).
Melting point: mp 110-111°
Toxicity data: LD50 orally in mice: 1530 mg/kg (Cavalleri)
Therap-Cat: Antiprotozoal (Trichomonas).
Keywords: Antiprotozoal (Trichomonas).

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