Mitotane
Title: Mitotane
CAS Registry Number: 53-19-0
CAS Name: 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
Additional Names: 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane; 2,4¢-dichlorodiphenyldichloroethane; 2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; o,p¢-DDD
Manufacturers' Codes: CB-313
Trademarks: Lysodren (Calbiochem)
Molecular Formula: C14H10Cl4
Molecular Weight: 320.04
Percent Composition: C 52.54%, H 3.15%, Cl 44.31%
Literature References: Constituent of commercial DDD which contains about 10% of this o,p¢-isomer. Prepn from 2,2-dichloro-1-(o-chlorophenyl)ethanol with chlorobenzene in presence of H2SO4: Haller et al., J. Am. Chem. Soc. 67, 1600 (1945). Isoln from technical grade DDD: Cueto, Brown, Endocrinology 62, 326 (1958).
Properties: Crystals from pentane or methanol, mp 76-78°. Sol in ethanol, isooctane, carbon tetrachloride.
Melting point: mp 76-78°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Hormonal); Antiadrenals.

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