Mofarotene
Title: Mofarotene
CAS Registry Number: 125533-88-2
CAS Name: 4-[2-[4-[(1E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholine
Manufacturers' Codes: Ro 40-8757
Molecular Formula: C29H39NO2
Molecular Weight: 433.63
Percent Composition: C 80.32%, H 9.07%, N 3.23%, O 7.38%
Literature References: Anticancer aromatic analog of retinoic acid (arotinoid). Prepn: M. Klaus et al., EP 331983; eidem, US 4940707 (1989, 1990 both to Hoffmann-La Roche). Mode of action study: J. F. Eliason et al., Blood 86, 4516 (1995). Pharmacokinetics: B. Vallès et al., Eur. J. Drug Metab. Pharmacokinet. 20, 49 (1995). HPLC determn in plasma: R. Wyss et al., J. Chromatogr. A 729, 315 (1996). Mechanism of growth inhibition on pancreatic cancer cells: S. Kawa et al., Int. J. Cancer 72, 906 (1997). Clinical pharmacology in combination with cisplatin and etoposide: L. van Zuylen et al., Anti-Cancer Drugs 10, 361 (1999).
Properties: White crystals from ethyl acetate/hexane, mp 107-109°.
Melting point: mp 107-109°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Retinoids and Analogs.

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