Moxidectin
Title: Moxidectin
CAS Registry Number: 113507-06-5
CAS Name: (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)milbemycin B
Additional Names: 23-methyloxime LL-F282249a; (2aE,4E,5¢R,6R,6¢S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6¢-[(E)-1,3-dimethyl-1-butenyl]-5¢,6,6¢,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5¢,6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq]benzodioxacyclooctadecin-13,2¢-[2H]pyran]-4¢,17(3¢H)-dione 4¢-(E)-(O-methyloxime)
Manufacturers' Codes: CL-301423
Trademarks: Cydectin (Fort Dodge); Equest (Fort Dodge); Proheart 6 (Fort Dodge); Quest (Fort Dodge); Vetdectin (Fort Dodge)
Molecular Formula: C37H53NO8
Molecular Weight: 639.82
Percent Composition: C 69.46%, H 8.35%, N 2.19%, O 20.00%
Literature References: Semisynthetic macrolide antibiotic; 23-methyloxime analog of nemadectin, q.v.. Prepn: B. M. Bain et al., EP 237339 (1987 to Glaxo); G. Asato, D. J. France, EP 259779 (1988 to Am. Cyanamid). Efficacy in cattle against lice: J. D. Webb et al., J. Econ. Entomol. 84, 1266 (1991); against gastrointestinal nematodes: G. L. Zimmerman et al., Am. J. Vet. Res. 53, 1409 (1992); J. C. Williams et al., Vet. Rec. 131, 345 (1992); against psoroptic mange: J. F. Lonneux, B. Losson, Vet. Parasitol. 45, 147 (1992). Environmental effects on dung-burying beetles: G. T. Fincher, G. T. Wang, Southwest. Entomol. 17, 303 (1992).
Therap-Cat-Vet: Anthelmintic; antiparasitic.

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