Naled
Title: Naled
CAS Registry Number: 300-76-5
CAS Name: Phosphoric acid 1,2-dibromo-2,2-dichloroethyl dimethyl ester
Additional Names: dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate; bromchlophos
Manufacturers' Codes: ENT-24988; OMS-75; RE-4355
Trademarks: Bromex; Dibrom (Amvac)
Molecular Formula: C4H7Br2Cl2O4P
Molecular Weight: 380.78
Percent Composition: C 12.62%, H 1.85%, Br 41.97%, Cl 18.62%, O 16.81%, P 8.13%
Literature References: Cholinesterase inhibitor. Prepn: GB 855157; Ospenson, Kohn, US 2971882 (1960, 1961 both to California Res. Corp.). Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).
Properties: Usually obtained as a liquid, slightly pungent odor, bp0.5 110°. d425 1.96. Has been crystallized, mp 26.5-27.5°. Vapor pressure at 20° about 2 ´ 10-3 mm Hg. Practically insol in water. Completely hydrolyzed by water within 48 hrs. Freely sol in aromatic and chlorinated hydrocarbons, ketones, alcohols. Sparingly sol in petroleum solvents and mineral oils. LD50 in male rats (mg/kg): 250 orally; 800 dermally (Gaines).
Melting point: mp 26.5-27.5°
Boiling point: bp0.5 110°
Density: d425 1.96
Toxicity data: LD50 in male rats (mg/kg): 250 orally; 800 dermally (Gaines)
CAUTION: Potential symptoms of overexposure are miosis, lacrimation; headache; chest tightness, wheezing and laryngeal spasm; salivation; cyanosis; anorexia, nausea, vomiting, abdominal cramps and diarrhea; weakness, twitching and paralysis; giddiness, ataxia and convulsions; low blood pressure; cardiac irregularities; irritation of skin and eyes. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 114.
Use: Insecticide; acaricide.

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