Nicaraven
Title: Nicaraven
CAS Registry Number: 79455-30-4
CAS Name: N,N¢-(1-Methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide
Additional Names: 1,2-bis(nicotinamido)propane; (±)-N,N¢-propylenedinicotinamide; AVS
Trademarks: Antevas (Chugai)
Molecular Formula: C15H16N4O2
Molecular Weight: 284.31
Percent Composition: C 63.37%, H 5.67%, N 19.71%, O 11.25%
Literature References: Hydroxyl radical scavenger. Prepn: T. Mori et al., EP 29602; eidem, US 4366161 (1981, 1982 both to Chugai); T. Doi et al., Synlett 1999, 1751. Effect on human platelet aggregation: T. Komiya et al., Clin. Neuropharmacol. 22, 11 (1999). Clinical trial in subarachnoid hemorrhage: T. Asano et al., J. Neurosurg. 84, 792 (1996). Review: K. K. Jain, Expert Opin. Invest. Drugs 9, 859-870 (2000).
Properties: Crystals from ethyl acetate, mp 156-157°. Sol in water.
Melting point: mp 156-157°
Therap-Cat: In treatment of vasospasm following subarachnoid hemorrhage.

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