Nicergoline
Title: Nicergoline
CAS Registry Number: 27848-84-6
CAS Name: (8b)-10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester)
Additional Names: 1-methyllumilysergol 8-(5-bromonicotinate) 10-methyl ether; 4,6,6a,7,8,9,10,10a-octahydro-10aa-methoxy-4,7-dimethylindolo[4,3-fg]quinoline-9-methanol 5-bromonicotinate; 8b-[(5-bromonicotinoyloxy)methyl]-1,6-dimethyl-10a-methoxyergoline; nicotergoline; nimergoline; MNE
Manufacturers' Codes: FI-6714
Trademarks: Cergodum (Duncan); Circo-Maren (Krewel); Dilasenil (Celtia); Duracebrol (Durachemie); Ergotop (Kwizda); Ergobel (Hormosan); Memoq (Gecke); Nicergolent (Ramon); Sermion (Farmitalia); Vasospan (Exa)
Molecular Formula: C24H26BrN3O3
Molecular Weight: 484.39
Percent Composition: C 59.51%, H 5.41%, Br 16.50%, N 8.67%, O 9.91%
Literature References: Prepn: Bernardi et al., US 3228943; Temperilli, DE 2112273 (1966, 1971, both to Farmitalia); Arcari et al., Experientia 28, 819 (1972). Series of articles on pharmacology, clinical studies, tolerability: Arzneim.-Forsch. 29, 1213-1316 (1979). Toxicity study: B. W. Neumann, F. Lauschner, ibid. 1206. Hemodynamic effects in the dog: ibid. 31, 1693 (1981). Use in acute myocardial infarction with diastolic hypertension: E. Triulzi et al., Farmaco Ed. Prat. 36, 449 (1981).
Properties: mp 136-138°. LD50 in male mice, rats (mg/kg): 860, 2800 orally; 46, 43 i.v. (Neumann, Lauschner).
Melting point: mp 136-138°
Toxicity data: LD50 in male mice, rats (mg/kg): 860, 2800 orally; 46, 43 i.v. (Neumann, Lauschner)
Therap-Cat: Vasodilator (cerebral, peripheral).
Keywords: a-Adrenergic Blocker; Vasodilator (Cerebral); Vasodilator (Peripheral).

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