Niflumic Acid
Title: Niflumic Acid
CAS Registry Number: 4394-00-7
CAS Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
Additional Names: 2-(a,a,a-trifluoro-m-toluidino)nicotinic acid; 2-[3-(trifluoromethyl)anilino]nicotinic acid
Manufacturers' Codes: UP-83
Trademarks: Actol (Fournier); Forenol (Roemmers); Landruma (Landerln); Nifluril
Molecular Formula: C13H9F3N2O2
Molecular Weight: 282.22
Percent Composition: C 55.33%, H 3.21%, F 20.20%, N 9.93%, O 11.34%
Literature References: Prepn: NL 6414717; C. Hoffmann, A. Faure, US 3415834 (1965, 1968 both to Lab. U.P.S.A.); eidem, Bull. Soc. Chim. Fr. 1966, 2316. Pharmacological and metabolic studies: Glasson et al., Biochem. Pharmacol. 18, 633 (1969); Boissier et al., Therapie 26, 211 (1971). Toxicity data: J. R. J. Sorenson, J. Med. Chem. 19, 135 (1976). Determn in human plasma by GLC: G. Houin et al., J. Chromatogr. 223, 351 (1981).
Properties: Crystals from ethanol, mp 204°. LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson).
Melting point: mp 204°
Toxicity data: LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson)
 
Derivative Type: b-Morpholinoethyl ester
CAS Registry Number: 65847-85-0
Additional Names: Morniflumate
Trademarks: Flomax (Chiesi); Nifluril (suppositories) (UPSA)
Molecular Formula: C19H20F3N3O3
Molecular Weight: 395.38
Percent Composition: C 57.72%, H 5.10%, F 14.42%, N 10.63%, O 12.14%
Literature References: Prepn of the ester HCl: Hoffmann, DE 1802777; idem, US 3708481 (1969, 1973 both to Hexachimie).
 
Derivative Type: Phthalidyl ester see Talniflumate
 
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives.

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