Nifuradene
Title: Nifuradene
CAS Registry Number: 555-84-0
CAS Name: 1-[[(5-Nitro-2-furanyl)methylene]amino]-2-imidazolidinone
Additional Names: oxafuradene (rescinded)
Manufacturers' Codes: NF-246; NSC-6470
Trademarks: Renafur (Eaton)
Molecular Formula: C8H8N4O4
Molecular Weight: 224.17
Percent Composition: C 42.86%, H 3.60%, N 24.99%, O 28.55%
Literature References: Prepn: Gever, Michels, US 2746960 (1956 to Norwich Pharm.); eidem, J. Am. Chem. Soc. 78, 5349 (1956); Michels, US 2776979 (1957 to Norwich Pharm.). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Lemon-yellow solid from nitromethane, mp 261.5-263° (dec). Turns orange on standing, on washing with ethanol or on heating at 75-85°. uv max (water): 387.5, 273 nm (e 17550, 13200). Soly in water: 88-109 mg/l. LD50 orally in rats: 1681 mg/kg (Goldenthal).
Melting point: mp 261.5-263° (dec)
Absorption maximum: uv max (water): 387.5, 273 nm (e 17550, 13200)
Toxicity data: LD50 orally in rats: 1681 mg/kg (Goldenthal)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Nitrofurans.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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