Nifurzide
Title: Nifurzide
CAS Registry Number: 39978-42-2
CAS Name: 5-Nitro-2-thiophenecarboxylic acid [3-(5-nitro-2-furanyl)-2-propenylidene]hydrazide
Additional Names: N1-(5-nitro-2-furylacrylidene)-N2-(5-nitro-2-thenoyl)hydrazine; 5-nitro-2-thiophenecarboxylic acid [3-(5-nitro-2-furyl)allylidene]hydrazide
Trademarks: Ricridene (Lipha)
Molecular Formula: C12H8N4O6S
Molecular Weight: 336.28
Percent Composition: C 42.86%, H 2.40%, N 16.66%, O 28.55%, S 9.54%
Literature References: Bactericidal agent related to nitrofurazone, q.v. Prepn: E. Szarvasi, L. Fontaine, DE 2200375; eidem, US 3847911 (1972, 1974 both to Lipha); E. Szarvasi et al., J. Med. Chem. 16, 281 (1973). Mode of action study: A. Delsarte et al., Antimicrob. Agents Chemother. 19, 477 (1981).
Properties: Yellow crystals from DMF/ether, mp 235-236°. LD50 orally in mice: 3200 mg/kg (Szarvasi, Fontaine, 1972).
Melting point: mp 235-236°
Toxicity data: LD50 orally in mice: 3200 mg/kg (Szarvasi, Fontaine, 1972)
Therap-Cat: Anti-infective.
Keywords: Antiseptic/Disinfectant; Nitrofurans.

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