Norfenefrine
Title: Norfenefrine
CAS Registry Number: 536-21-0
CAS Name: a-(Aminomethyl)-3-hydroxybenzene methanol
Additional Names: a-(aminomethyl)-m-hydroxybenzyl alcohol; 1-(m-hydroxyphenyl)-2-aminoethanol; m-hydroxyphenylethanolamine; norphenylephrine
Molecular Formula: C8H11NO2
Molecular Weight: 153.18
Percent Composition: C 62.73%, H 7.24%, N 9.14%, O 20.89%
Literature References: Chem synthesis: Sachs, FR 866569 (1941), C.A. 43, 5043c (1949); Legerlotz, US 2312916 (1943 to Ciba); Credner, Neugebauer, Arzneim.-Forsch. 3, 462 (1953); Bretschneider, Hörmann, Monatsh. Chem. 84, 1021 (1953). Synthesis and resolution: D'Amico et al., Chim. Ind. (Milan) 38, 93 (1956). Biosynthesis: Hartman et al., J. Am. Chem. Soc. 77, 816 (1955). Activity studies: Gersmeyer, Albrecht, Med. Welt 1966, 657. Metabolism: Barac, C.R. Seances Soc. Biol. Ses Fil. 155, 1598 (1961).
 
Derivative Type: dl-Form hydrochloride
CAS Registry Number: 15308-34-6
Trademarks: Coritat (Green Cross); Depot-Novadral (Diwag); Energona (Maurer); Esbuphon (Schaper & Brðmer); Molycor-R (Mepha); Novadral (Diwag); Stagural (Stada-Chemie); Tonolift (Teisan); Vingsal (Stroschein); Zondel (Grelan)
Molecular Formula: C8H11NO2.HCl
Molecular Weight: 189.64
Percent Composition: C 50.67%, H 6.38%, N 7.39%, O 16.87%, Cl 18.69%
Properties: Crystals, mp 159-160°. uv max: 274 nm (E1%1cm 91.21). Freely soluble in water.
Melting point: mp 159-160°
Absorption maximum: uv max: 274 nm (E1%1cm 91.21)
 
Therap-Cat: Adrenergic.
Keywords: a-Adrenergic Agonist.

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