NPPB
Title: NPPB
CAS Registry Number: 107254-86-4
CAS Name: 5-Nitro-2-[(3-phenylpropyl)amino]benzoic acid
Manufacturers' Codes: HOE-144
Molecular Formula: C16H16N2O4
Molecular Weight: 300.31
Percent Composition: C 63.99%, H 5.37%, N 9.33%, O 21.31%
Literature References: Inhibits efflux of ion channels; specificity is cell type dependent. Prepn: H. C. Englert et al., DE 3528048; eidem, US 4994493 (1987, 1991 both to Hoechst). Synthesis and characterization as potassium channel blocker: K. R. Giles et al., Bioorg. Med. Chem. Lett. 13, 293 (2003). Blocking kinetics of chloride channels: J. Dreinhöfer et al., Biochim. Biophys. Acta 946, 135 (1988). Effect on chloride ion transport: B. R. Branchini et al., Biochem. Biophys. Res. Commun. 176, 459 (1991); eidem, Arch. Biochem. Biophys. 318, 221 (1995); J.-A. Kim et al., Biochem. Biophys. Res. Commun. 309, 291 (2003).
Properties: Yellow crystals from isopropanol, mp 178-180°. Soly (mg/ml): 25 DMSO, 10 ethanol.
Melting point: mp 178-180°
Use: Biochemical probe primarily as a Cl- channel blocker.

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