Octyl Salicylate
Title: Octyl Salicylate
CAS Registry Number: 118-60-5
CAS Name: 2-Hydroxybenzoic acid 2-ethylhexyl ester
Additional Names: 2-ethylhexyl salicylate; octisalate
Trademarks: Eusolex OS (Merck KGaA); Neo Heliopan OS (Symrise)
Molecular Formula: C15H22O3
Molecular Weight: 250.33
Percent Composition: C 71.97%, H 8.86%, O 19.17%
Literature References: UV-B filter in sunscreens and cosmetics. Prepn: F. H. McMillan, J. A. King, J. Am. Chem. Soc. 67, 2271 (1945). In vitro skin penetration studies: K. A. Walters et al., Food Chem. Toxicol. 35, 1219 (1997); R. Jiang et al., J. Pharm. Sci. 86, 791 (1997). Determn in sun protection lotions by GC-MS: K. W. Ro et al., J. Chromatogr. A 688, 375 (1994); by HPTLC: E. Westgate, J. Sherma, Am. Lab. 32, 13 (2000).
Properties: Colorless to pale yellow liquid, bp21 189-190°. nD25 1.5018. Misc with cosmetic oils, silicone oils.
Boiling point: bp21 189-190°
Index of refraction: nD25 1.5018
Use: Solvent for solid sunscreens.
Therap-Cat: Ultraviolet screen.
Keywords: Ultraviolet Screen.

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