Octyl Cyanoacrylate
Title: Octyl Cyanoacrylate
CAS Registry Number: 6701-17-3
CAS Name: 2-Cyano-2-propenoic acid octyl ester
Additional Names: ocrilate; ocrylate; n-octyl a-cyanoacrylate; capryl a-cyanoacrylate; octyl 2-cyanoacrylate
Trademarks: Dermabond (Ethicon); Nexaband (Closure Medical); Soothe-N-Seal (Colgate-Palmolive)
Molecular Formula: C12H19NO2
Molecular Weight: 209.28
Percent Composition: C 68.87%, H 9.15%, N 6.69%, O 15.29%
Literature References: Biodegradable, topical surgical glue; upon contact with tissue anions, monomer rapidly polymerizes to form a strong adhesive. Preparative method: A. E. Ardis, US 2467927 (1949 to B. F. Goodrich). Prepn, polymerization and degradation: F. Leonard et al., J. Appl. Polym. Sci. 10, 259 (1966). Biocompatibility, histomorphology, and clinical characteristics: A. Nitsch et al., Aesth. Plast. Surg. 29, 53 (2005). Clinical trial for closure of lacerations: J. Quinn et al, J. Am. Med. Assoc. 277, 1527 (1997); of lacerations and incisions: A. J. Singer et al., Surgery 131, 270 (2002); for repair of inguinal hernia: G. Miyano et al., J. Pediatr. Surg. 39, 1867 (2004).
Properties: bp1.8 117°; d20 0.931; n20D 1.4489. Surface tension: 29.18 dynes/cm.
Boiling point: bp1.8 117°
Index of refraction: n20D 1.4489
Density: d20 0.931
Derivative Type: Polymer
CAS Registry Number: 26877-34-9
Additional Names: Poly(octyl cyanoacrylate)
Therap-Cat: Tissue adhesive.
Therap-Cat-Vet: Tissue adhesive.
Keywords: Tissue Adhesive.

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