Opromazine
Title: Opromazine
CAS Registry Number: 969-99-3
CAS Name: 2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine 5-oxide
Additional Names: 2-chloro-10-[3-(dimethylamino)propyl]phenothiazine 5-oxide; 10-(g-dimethylaminopropyl)-3-chlorphenothiazine 9-oxide; 5-oxychlorpromazine; chlorpromazine sulfoxide
Trademarks: Secotil
Molecular Formula: C17H19ClN2OS
Molecular Weight: 334.86
Percent Composition: C 60.98%, H 5.72%, Cl 10.59%, N 8.37%, O 4.78%, S 9.58%
Literature References: Metabolite of chlorpromazine, q.v.: Salzman, Brodie, J. Pharmacol. Exp. Ther. 118, 46 (1956). Preparation by enzymatic oxidation of chlorpromazine: Gillette, Kamm, ibid. 130, 262 (1960). Synthesis: FR 1167653 (1958 to Rhône-Poulenc). Toxicity data: Minami, Yoshimoto, Nara Igaku Zasshi 8, 50 (1957), C.A. 51, 16966a (1957).
Properties: Crystals, mp 115°. LD50 s.c. in mice: 102 mg/kg (Minami, Yoshimoto).
Melting point: mp 115°
Toxicity data: LD50 s.c. in mice: 102 mg/kg (Minami, Yoshimoto)

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