Oxazepam
Title: Oxazepam
CAS Registry Number: 604-75-1
CAS Name: 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
Additional Names: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Manufacturers' Codes: Wy-3498
Trademarks: Adumbran (Boehringer, Ing.); Azutranquil (Azupharma); Durazepam (Merck KGaA); Hilong (Wyeth); Limbial (Chiesi); Noctazepam (Hexal); Praxiten (Teofarma); Serax (Wyeth); Serenid (Wyeth); Serepax (Wyeth); Séresta (Biodim); Serpax (Wyeth); Sobril (Pharmacia); Uskan (Desitin)
Molecular Formula: C15H11ClN2O2
Molecular Weight: 286.71
Percent Composition: C 62.84%, H 3.87%, Cl 12.37%, N 9.77%, O 11.16%
Literature References: Prepn: Bell, Childress, J. Org. Chem. 27, 1691 (1962); NL 298071; S. C. Bell, US 3296249 (1965, 1967 both to American Home Prod.). Crystal and molecular structure: G. Gilli et al., Acta Crystallogr. B34, 2826 (1978). Metabolic studies: Sisenwine et al., Arzneim.-Forsch. 22, 682 (1972); Knowles, Ruelius, ibid. 687. Pharmacokinetics: D. J. Greenblatt, Clin. Pharmacokinet. 6, 89 (1981). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: C. M. Shearer, C. R. Pilla, Anal. Profiles Drug Subs. 3, 441-464 (1974). Review: Acta Psychiatr. Scand. Suppl. 274, R. Chinnery, A. Sundwall, Eds. (1978) 128 pp.
Properties: Crystals from alcohol, mp 205-206°. Sol in alcohol, chloroform, dioxane. Practically insol in water. LD50 in mice, rats (mg/kg): >5010, >5010 orally (Goldenthal).
Melting point: mp 205-206°
Toxicity data: LD50 in mice, rats (mg/kg): >5010, >5010 orally (Goldenthal)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.

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