Pentosan Polysulfate
Title: Pentosan Polysulfate
CAS Registry Number: 37300-21-3
CAS Name: Xylan hydrogen sulfate
Additional Names: xylan polysulfate
Manufacturers' Codes: CB-8061
Literature References: Semi-synthetic sulfated polyanion composed of b-D-xylopyranose residues with properties similar to heparin, q.v. Mol wt ranges from 1500 to 5000. Prepn: CH 293566 (1953 to Wander), C.A. 49, 1787h (1955). Anticoagulant activity: B. Paramelle, Therapie 17, 719 (1962); J.-B., Dureux et al., ibid. 19, 879 (1964). Pharmacokinetics: R. Taugner et al., Arch. Int. Pharmacodyn. 189, 250 (1971). Effects on aggregation of human blood platelets: G. Kindness et al., Thromb. Res. 16, 97 (1979). Comparison of pentosan polysulfate with heparin: C. Soria et al., ibid. 19, 455 (1980); M. Ryde et al., ibid. 23, 435 (1981); A.-M. Fischer et al., Thromb. Haemostasis 47, 104, 109 (1982). Mechanism of antiadherence activity in urinary bladder: C. L. Parsons et al., Science 208, 605 (1980); eidem, Infect. Immun. 27, 876 (1980). Clinical trials in interstitial cystitis: A. Fritjofsson et al., J. Urol. 138, 508 (1987); S. G. Mulholland et al., Urology 6, 552 (1990).
 
Derivative Type: Sodium salt
CAS Registry Number: 37319-17-8
Additional Names: Sodium pentosan polysulfate; sodium xylan polysulfate
Trademarks: Cartrophen (Univet); Elmiron (Baker Norton); Fibrase (SK & F); Fibrezym (Bene-Arzneimittel); Hémoclar (Sanofi Winthrop); SP-54 (Bene-Chemie); Thrombocid (Bene-Chemie)
Properties: White odorless powder, slightly hygroscopic. [a]D20 -57°. pH of 10% aq soln ~6.0. nD20 of 10% aq soln: 1.344. Sol in water.
Optical Rotation: [a]D20 -57°
Index of refraction: nD20 of 10% aq soln: 1.344
 
Therap-Cat: In treatment of interstitial cystitis; antithrombotic.
Therap-Cat-Vet: Anti-inflammatory.
Keywords: Anticoagulant.

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