Perfluoropropane
Title: Perfluoropropane
CAS Registry Number: 76-19-7
CAS Name: Octafluoropropane
Additional Names: 1,1,1,2,2,3,3,3-octafluoropropane; perflutren
Manufacturers' Codes: K-218; PFC-218; R-218
Trademarks: Ispan (Scott Med. Prod.)
Molecular Formula: C3F8
Molecular Weight: 188.02
Percent Composition: C 19.16%, F 80.84%
Literature References: Non-ozone depleting fluorocarbon; formulated for surgical and diagnostic use. Prepn: J. H. Simons, L. P. Block, J. Am. Chem. Soc. 61, 2962 (1939). See also: J. H. Simons, US 2456027 (1948 to Minnesota Mining Manuf). Physical properties: J. A. Brown, J. Chem. Eng. Data 8, 106 (1963). Thermophysical properties: D. R. Defibaugh, M. R. Moldover, ibid. 42, 160 (1997). Clinical experience in repair of retinal detachment: N. R. Sabates et al., Retina 16, 7 (1996). Review of properties and description: Matheson Gas Data Book, W. Braker, A. L. Mossman, Eds. (Matheson, Lyndhurst, NJ, 6th ed., 1980) p 590-595; of electron interactions for modeling behavior: L. G. Christophorou, J. K. Oltoff, J. Phys. Chem. Ref. Data 27, 889-913 (1998).
Properties: Colorless, nonflammable gas. mp -183°. bp -36.7°. d20 (liq) 1.352. Critical temp 71.9°. Critical press 25.45 atm. Critical density 0.629.
Melting point: mp -183°
Boiling point: bp -36.7°
Density: d20 (liq) 1.352
 
Derivative Type: Human albumin microsphere suspension
Manufacturers' Codes: FS-069
Trademarks: Optison (GE Healthcare)
Literature References: Clinical study as echocardiographic contrast agent: J. L. Cohen et al., J. Am. Coll. Cardiol. 32, 746 (1998). Toxicology and safety study: Y. Greener et al., Int. J. Toxicol. 17, 631 (1998). Physical and biochemical stability: S. Podell et al., Biotechnol. Appl. Biochem. 30, 213 (1999). Review of diagnostic use: L. N. Clark, H. C. Dittrich, Am. J. Cardiol. 86, Suppl., 14G-18G (2000).
Properties: Mean microsphere particle diameter: 3.0 - 4.5 mm.
 
Derivative Type: Lipid microsphere suspension
Manufacturers' Codes: DMP-115; DMX-115; MRX-115
Trademarks: Definity (BMS)
Literature References: Preparative method: E. C. Inger, US 5874062 (1999 to ImaRx Pharm.). Clinical evaluation in echocardiography: D. W. Kitzman et al., Am. J. Cardiol. 86, 669 (2000).
Properties: Mean microsphere particle diameter: 1.1 - 3.3 mm.
 
Use: High voltage insulating gas; refrigerant when combined with chlorofluoro hydrocarbons; plasma processing gas; fire protection agent.
Therap-Cat: Diagnostic aid (ultrasound contrast agent). Adjunct in repair of retinal detachment.
Keywords: Diagnostic Aid (Ultrasound Contrast Agent).

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