Perlapine
Title: Perlapine
CAS Registry Number: 1977-11-3
CAS Name: 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Additional Names: 6-(4-methyl-1-piperazinyl)morphanthridine
Manufacturers' Codes: AW-14¢2333; HF-2333; MP-11
Trademarks: Hypnodin (Takeda)
Molecular Formula: C19H21N3
Molecular Weight: 291.39
Percent Composition: C 78.32%, H 7.26%, N 14.42%
Literature References: Prepn: GB 1006156; J. Schmutz, F. Hunziker, US 3389139 (1965, 1968 both to Wander); Hunziker et al., Helv. Chim. Acta 49, 1433 (1966). Pharmacology: Y. Take et al., J. Takeda Res. Lab. 29, 416 (1970); G. Stille et al., Psychopharmacologia 28, 325 (1973). Toxicology study: H. Yokotani et al., J. Takeda Res. Lab. 29, 441 (1970).
Properties: Yellow, prismatic crystals from acetone-petrol ether, mp 136-138°. LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani).
Melting point: mp 136-138°
Toxicity data: LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani)
Therap-Cat: Hypnotic.
Keywords: Sedative/Hypnotic.

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