Phencyclidine
Title: Phencyclidine
CAS Registry Number: 77-10-1
CAS Name: 1-(1-Phenylcyclohexyl)piperidine
Additional Names: angel dust; HOG; PCP
Manufacturers' Codes: CI-395
Molecular Formula: C17H25N
Molecular Weight: 243.39
Percent Composition: C 83.89%, H 10.35%, N 5.75%
Literature References: Prepn: GB 836083 and Godefroi et al., US 3097136 (1960, 1963 to Parke, Davis); V. H. Maddox et al., J. Med. Chem. 8, 230 (1965). Pharmacology: G. Chen et al., J. Pharmacol. Exp. Ther. 127, 241 (1959); J. C. Munch, Bull. Narc. 26, 9 (1974). Human metabolism: L. K. Wong, K. Biemann, Biomed. Mass Spectrom. 2, 204 (1975). Toxicity: K. Bailey et al., J. Pharm. Pharmacol. 28, 713 (1976). Extensive bibliography: R. L. Balster, R. S. Pross, J. Psychedelic Drugs 10, 1-15 (1978). Review: R. E. Garey, ibid. 11, 265-275 (1979). Review of neuropharmacology: K. M. Johnson, S. M. Jones, Annu. Rev. Pharmacol. Toxicol. 30, 707-750 (1990).
Properties: Colorless crystals, mp 46-46.5°. bp1.0 135-137°. uv max (0.1N HCl): 252, 257.5, 262, 268.5 nm (E1%1cm 7.9, 11.2, 13.0, 9.7).
Melting point: mp 46-46.5°
Boiling point: bp1.0 135-137°
Absorption maximum: uv max (0.1N HCl): 252, 257.5, 262, 268.5 nm (E1%1cm 7.9, 11.2, 13.0, 9.7)
 
Derivative Type: Hydrochloride
CAS Registry Number: 956-90-1
Trademarks: Sernyl; Sernylan
Molecular Formula: C17H25N.HCl
Molecular Weight: 279.85
Percent Composition: C 72.96%, H 9.36%, N 5.01%, Cl 12.67%
Properties: Crystals from 2-propanol, mp 233-235°. uv max (ethanol): 254, 258, 262.5, 269 nm (E1%1cm 7.9, 10.8, 12.7, 10.0). LD50 orally in mice: 76.5 mg/kg (Bailey).
Melting point: mp 233-235°
Absorption maximum: uv max (ethanol): 254, 258, 262.5, 269 nm (E1%1cm 7.9, 10.8, 12.7, 10.0)
Toxicity data: LD50 orally in mice: 76.5 mg/kg (Bailey)
 
Derivative Type: Hydrobromide
Properties: Crystals, mp 214-218°.
Melting point: mp 214-218°
 
CAUTION: This is a controlled substance (depressant): 21 CFR, 1308.12. The ethylamine, pyrrolidine and thiophene analogs are controlled substances (hallucinogens): 21 CFR, 1308.11.
Therap-Cat: Anesthetic (intravenous).
Therap-Cat-Vet: Analgesic; anesthetic.
Keywords: Anesthetic (Intravenous).

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