Picotamide
Title: Picotamide
CAS Registry Number: 32828-81-2
CAS Name: 4-Methoxy-N,N¢-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
Additional Names: 4-methoxy-N,N¢-bis(3-pyridylmethyl)isophthalamide; N,N¢-bis(3-picolyl)-4-methoxyisophthalamide
Manufacturers' Codes: G-137
Molecular Formula: C21H20N4O3
Molecular Weight: 376.41
Percent Composition: C 67.01%, H 5.36%, N 14.88%, O 12.75%
Literature References: Prepn: R. Selleri et al., Chim. Ther. 6, 203 (1971); G. Orzalesi, R. Selleri, FR 2100850 C.A. 77, 164502f (1972); prepn and use as inhibitor of blood platelet aggregation: eidem, US 3973026 (1972, 1976 both to Soc. Italo-Brit. L. Manetti-H. Roberts). Crystal structure of monohydrate: E. Foresti et al., Acta Crystallogr. C42, 220 (1986). Mechanism of action study: M. Berrettini et al., Boll. Soc. Ital. Biol. Sper. 59, 309 (1983). Clinical studies: R. Schmutzler et al., Age Ageing 7, 246 (1978); V. Coto et al., Minerva Cardioangiol. 34, 601 (1986).
Properties: Crystalline powder from benzene, mp 124°. LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976).
Melting point: mp 124°
Toxicity data: LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976)
 
Derivative Type: Monohydrate
CAS Registry Number: 80530-63-8
Trademarks: Plactidil (Novartis)
Molecular Formula: C21H20N4O3.H2O
Molecular Weight: 394.42
Percent Composition: C 63.95%, H 5.62%, N 14.20%, O 16.23%
 
Therap-Cat: Antithrombotic; fibrinolytic; anticoagulant.
Keywords: Anticoagulant; Antithrombotic.

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