Pindolol
Title: Pindolol
CAS Registry Number: 13523-86-9
CAS Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Additional Names: 4-[2-hydroxy-3-(isopropylamino)propoxy]indole; prinodolol
Manufacturers' Codes: LB-46
Trademarks: Betapindol (Helvepharm); Blocklin L (Shionogi); Decreten (Dumex); Pectobloc (Kytta-Siegfried); Pinbetol (Dolorgiet); Pindoptan (Kanoldt); Visken (Novartis)
Molecular Formula: C14H20N2O2
Molecular Weight: 248.32
Percent Composition: C 67.71%, H 8.12%, N 11.28%, O 12.89%
Literature References: Mixed b-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Prepn: NL 6601040; F. Troxler, A. Hofmann, US 3471515 (1966, 1969 both to Sandoz). HPLC determn in plasma: H. Smith, J. Chromatogr. 415, 95 (1987). Symposia on cardiovascular pharmacology and clinical studies: Am. Heart J. 104, Suppl. 2, pt. 2, 333-520 (1982); Br. J. Clin. Pharmacol. 13, Suppl. 2, 143S-450S (1982). Effect on serotonin levels in rat brain: L. J. Dreshfield et al., Neurochem. Res. 21, 557 (1996). Clinical trial with fluoxetine, q.v., in depression: V. Pérez et al., Lancet 349, 1594 (1997).
Properties: Crystals from ethanol, mp 171-173°.
Melting point: mp 171-173°
Therap-Cat: Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antiglaucoma; Antihypertensive; Aryloxypropanolamine Derivatives.

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