Pipoxolan Hydrochloride
Title: Pipoxolan Hydrochloride
CAS Registry Number: 18174-58-8
CAS Name: 5,5-Diphenyl-2-[2-(1-piperidinyl)ethyl]-1,3-dioxolan-4-one hydrochloride
Additional Names: 2-(b-N-piperidylethyl)-4,4-diphenyl-1,3-dioxolan-5-one hydrochloride
Manufacturers' Codes: BR-18
Trademarks: Rowapraxin (Rowa-Wagner)
Molecular Formula: C22H26ClNO3
Molecular Weight: 387.90
Percent Composition: C 68.12%, H 6.76%, Cl 9.14%, N 3.61%, O 12.37%
Literature References: Prepn: M. Pailer et al., Monatsh. Chem. 99, 891 (1968); GB 1109959 and BE 719230 (1968, 1969 to Rowa-Wagner). Pharmacology and acute toxicity: K. Morsdorf, H. Wengenroth, Pharmacology 3, 193 (1970).
Properties: Crystals from isopropyl alc, mp 207-209°. Soluble in water; stable to mild attack by acids or bases. LD50 in rats, mice (mg/kg): 1500, 700 orally; 60, 35 i.v.; 130, 130 i.p.; in rats (mg/kg): >300 s.c. (Morsdorf).
Melting point: mp 207-209°
Toxicity data: LD50 in rats, mice (mg/kg): 1500, 700 orally; 60, 35 i.v.; 130, 130 i.p.; in rats (mg/kg): >300 s.c. (Morsdorf)
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.

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