Polythiazide
Title: Polythiazide
CAS Registry Number: 346-18-9
CAS Name: 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 2-methyl-3-(b,b,b-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide
Trademarks: Drenusil (Pfizer); Nephril (Pfizer); Renese (Pfizer)
Molecular Formula: C11H13ClF3N3O4S3
Molecular Weight: 439.88
Percent Composition: C 30.03%, H 2.98%, Cl 8.06%, F 12.96%, N 9.55%, O 14.55%, S 21.87%
Literature References: Prepn: J. M. McManus, US 3009911 (1961 to Pfizer). Comprehensive description: T. Negendra Varo Prasad, Anal. Profiles Drug Subs. 20, 665-692 (1991).
Properties: Crystals from isopropanol, mp 202.5°. Sol in methanol and acetone. Practically insol in water and chloroform. Sol in aq solns made alkaline with carbonates or hydroxides of the alkali metals. Rate of decompn increases with increase in pH.
Melting point: mp 202.5°
Therap-Cat: Diuretic, antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.

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