Prajmaline
Title: Prajmaline
CAS Registry Number: 35080-11-6
CAS Name: (17R,21a)-17,21-Dihydroxy-4-propylajmalanium
Additional Names: N4-propylajmalinium; prajmalium; N-propylajmaline
Molecular Formula: [C23H33N2O2]+
Literature References: Prepn: J. Keck, Z. Naturforsch. 18b, 177 (1963); A. Bonati, E. Bombardelli, Farmaco Ed. Sci. 18, 851 (1963); J. Keck, DE 1154120 (1963 to Thomae); idem, US 3414577 (1968 to Boehringer, Ing.). Pharmacology: R. Koch, Arzneim.-Forsch. 22, 2079 (1972); H. M. Mertens et al., ibid. 23, 642 (1973); K.-W. Diederich, D. Boyksen, ibid. 1302. Toxicology: G. Von Philipsborn, B. Stalder, ibid. 22, 2085 (1972). Pharmacokinetics: A. T. Trompler et al., ibid. 33, 436 (1983). Mechanism of action: H. Langenfeld et al., J. Cardiovasc. Pharmacol. 15, 338 (1990). GC/MS determn in urine: H. H. Maurer, Arch. Toxicol. 64, 218 (1990). Clinical comparison with tocainide, q.v.: B. Schwartzkopff et al., Arzneim.-Forsch. 33, 153 (1983).
 
Derivative Type: Hydrogen tartrate
CAS Registry Number: 2589-47-1
Additional Names: Prajmaline bitartrate; NPAB
Manufacturers' Codes: GT-1012
Trademarks: Neo-Gilurytmal (Kali-Chemie)
Molecular Formula: C23H33N2O2.C4H5O6
Molecular Weight: 518.60
Percent Composition: C 62.53%, H 7.39%, N 5.40%, O 24.68%
Properties: White crystals from ethanol + ether, mp 149-152°. LD50 in mice (mg/kg): 43 orally; 1.7 i.v. (Von Philipsborn, Stalder).
Melting point: mp 149-152°
Toxicity data: LD50 in mice (mg/kg): 43 orally; 1.7 i.v. (Von Philipsborn, Stalder)
 
Therap-Cat: Antiarrhythmic.
Keywords: Antiarrhythmic.

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