Pramoxine
Title: Pramoxine
CAS Registry Number: 140-65-8
CAS Name: 4-[3-(4-Butoxyphenoxy)propyl]morpholine
Additional Names: p-butoxyphenyl g-morpholinopropyl ether; g-morpholinopropyl 4-n-butoxyphenyl ether; pramocaine; proxazocain
Molecular Formula: C17H27NO3
Molecular Weight: 293.40
Percent Composition: C 69.59%, H 9.28%, N 4.77%, O 16.36%
Literature References: Prepn: Wright, Moore, J. Am. Chem. Soc. 73, 2281 (1951); 76, 4396 (1954); US 2870151 (1959 to Abbott). Pharmacology: O. Blanpin, Anesth. Analg. Reanimat. 14, 225 (1957). Toxicity studies: J. L. Schmidt et al., Toxicol. Appl. Pharmacol. 1, 454 (1959); S. Monash, D. Gibbs, Anesth. Analg. 38, 265 (1959).
Properties: bp6 196°; bp2.8 183-184°. LD50 in mice (mg/kg): 300 i.p., 900 s.c. (Monash, Gibbs).
Boiling point: bp6 196°; bp2.8 183-184°
Toxicity data: LD50 in mice (mg/kg): 300 i.p., 900 s.c. (Monash, Gibbs)
 
Derivative Type: Hydrochloride
CAS Registry Number: 637-58-1
Trademarks: Proctofoam-NS (Schwarz); Tronolane (Abbott); Tronothane (Abbott)
Molecular Formula: C17H27NO3.HCl
Molecular Weight: 329.86
Percent Composition: C 61.90%, H 8.56%, N 4.25%, O 14.55%, Cl 10.75%
Properties: Crystals, mp 181-183°. Sol in water. LD50 i.v. in mice: 79.5 ±2.7 mg/kg (Schmidt). LD50 in mice (mg/kg): 300 i.p., 750 s.c. (Monash, Gibbs).
Melting point: mp 181-183°
Toxicity data: LD50 i.v. in mice: 79.5 ±2.7 mg/kg (Schmidt); LD50 in mice (mg/kg): 300 i.p., 750 s.c. (Monash, Gibbs)
 
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).

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