Pranoprofen
Title: Pranoprofen
CAS Registry Number: 52549-17-4
CAS Name: a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
Additional Names: 2-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid
Manufacturers' Codes: Y-8004
Trademarks: Niflan (Yoshitomi)
Molecular Formula: C15H13NO3
Molecular Weight: 255.27
Percent Composition: C 70.58%, H 5.13%, N 5.49%, O 18.80%
Literature References: Prepn: M. Nakanishi et al., DE 2337052; eidem, US 3931205 (1974, 1976 both to Yoshitomi); eidem, Yakugaku Zasshi 96, 99 (1976), C.A. 84, 135515b (1976). Physicochemical properties: M. Nobutoki, Y. Ota, Iyakuhin Kenkyu 7, 200 (1976), C.A. 88, 110468h (1978). Absorption, metabolism, distribution, excretion: Y. Kato et al., Yakuri to Chiryo 4, 1473 (1976), C.A. 88, 130710j (1978). Pharmacological study: Y. Maruyama et al., Nippon Yakurigaku Zasshi 73, 113 (1977), C.A. 88, 276m (1978). Toxicity study: M. Edanaga et al., Iyakuhin Kenkyu 7, 211 (1976), C.A. 88, 131015y (1978).
Properties: Cryst from aq dioxane, mp 182-183°. LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga).
Melting point: mp 182-183°
Toxicity data: LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.

Others monographs:
SebacilThymostimulinDanaparoidErgotamine
EnrofloxacinIndium TrichlorideVeratramineEtidronic Acid
Morphine3,5-Dinitrobenzoic AcidNandroloneMercuric Fluoride
Blasticidin SChlorpheniramineFerric HydroxideHydroprene
©2016 DrugLead US FDA&EMEA