Prenoxdiazine Hydrochloride
Title: Prenoxdiazine Hydrochloride
CAS Registry Number: 982-43-4
CAS Name: 1-[2-[3-(2,2-Diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]piperidine monohydrochloride
Additional Names: 3-(b,b-diphenylethyl)-5-(b-piperidinoethyl)-1,2,4-oxadiazole hydrochloride
Manufacturers' Codes: HK-256
Trademarks: Libexin (Chinoin); Lomapect (TAD); Tibexin (Christiaens)
Molecular Formula: C23H28ClN3O
Molecular Weight: 397.94
Percent Composition: C 69.42%, H 7.09%, Cl 8.91%, N 10.56%, O 4.02%
Literature References: Prepn: K. Harsanyi et al., HU 151748 (1964 to Chinoin), C.A. 62, 11821f (1965). Pharmacology: L. Tardos, I. Erdély, Arzneim.-Forsch. 16, 617 (1966). Stability study: E. Pandula et al., Acta Pharm. Hung. 38, 68 (1968). Review of pharmacology and clinical studies: K. Harsanyi et al., Boll. Chim. Farm. 112, 691 (1973).
Properties: Crystals from ethanol, mp 192-193°. LD50 in mice, rats (mg/kg): 920, >2000 orally; 34, 32 i.v. (Tardos, Erdély).
Melting point: mp 192-193°
Toxicity data: LD50 in mice, rats (mg/kg): 920, >2000 orally; 34, 32 i.v. (Tardos, Erdély)
Therap-Cat: Antitussive.
Keywords: Antitussive.

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