Promazine
Title: Promazine
CAS Registry Number: 58-40-2
CAS Name: N,N-Dimethyl-10H-phenothiazine-10-propanamine
Additional Names: 10-(3-dimethylaminopropyl)phenothiazine
Manufacturers' Codes: RP-3276; Wy-1094; A-145
Molecular Formula: C17H20N2S
Molecular Weight: 284.42
Percent Composition: C 71.79%, H 7.09%, N 9.85%, S 11.27%
Literature References: Prepd by heating a xylene soln of phenothiazine and 3-dimethylamino-1-chloropropane in the presence of sodamide: Charpentier, US 2519886 (1950 to Rhône-Poulenc).
Properties: Oily liq. Amine odor. Alkaline reaction. bp0.3 203-210°.
Boiling point: bp0.3 203-210°
 
Derivative Type: Hydrochloride
CAS Registry Number: 53-60-1
Trademarks: Liranol (Wyeth); Promwill (Will-Pharma); Prazine (Wyeth); Protactyl (Wyeth); Sparine (Wyeth); Talofen (Fournier)
Molecular Formula: C17H20N2S.HCl
Molecular Weight: 320.88
Percent Composition: C 63.63%, H 6.60%, N 8.73%, S 9.99%, Cl 11.05%
Properties: White to slightly yellow crystals, dec 181° (microblock). Oxidizes upon prolonged exposure to air and acquires a blue or pink color. Hygroscopic. One gram dissolves in about 3 ml water. Sol in methanol, ethanol, chloroform. Practically insol in ether, benzene. Aq solns are slightly acid to litmus. Incompatible with alkalies, oxidizing agents, heavy metals.
 
Therap-Cat: Antipsychotic.
Therap-Cat-Vet: Tranquilizer.
Keywords: Antipsychotic; Phenothiazines.

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