Propantheline Bromide
Title: Propantheline Bromide
CAS Registry Number: 50-34-0
CAS Name: N-Methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-2-propanaminium bromide
Additional Names: (2-hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate; b-diisopropylaminoethyl 9-xanthenecarboxylate methobromide
Trademarks: Corrigast (Searle); Ercotina (Orion-Farmos); Pro-Banthine (Roberts); Neo-Metantyl (Zambon); Pantheline (CP Protea)
Molecular Formula: C23H30BrNO3
Molecular Weight: 448.39
Percent Composition: C 61.61%, H 6.74%, Br 17.82%, N 3.12%, O 10.70%
Literature References: Synthetic quaternary ammonium anticholinergic. Prepn: Cusic, Robinson, J. Org. Chem. 16, 1921 (1951); US 2659732 (1953 to Searle). Metabolic studies: Beermann et al., Clin. Pharmacol. Ther. 13, 212 (1972).
Properties: Crystals from isopropanol + ether, mp 159-161°. Very soluble in water, alcohol, chloroform. Practically insol in ether, benzene.
Melting point: mp 159-161°
Therap-Cat: Antispasmodic; in treatment of urinary incontinence.
Keywords: Antimuscarinic; Antispasmodic.

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