Propyl Gallate
Title: Propyl Gallate
CAS Registry Number: 121-79-9
CAS Name: 3,4,5-Trihydroxybenzoic acid propyl ester
Additional Names: n-propyl gallate; gallic acid propyl ester; PG
Trademarks: Progallin P (Nipa); Tenox PG (Eastman)
Molecular Formula: C10H12O5
Molecular Weight: 212.20
Percent Composition: C 56.60%, H 5.70%, O 37.70%
Literature References: Spectrophotometric determn: C. S. Sastry et al., Talanta 29, 917 (1982). Effects on survival of Saccharomyces cerevisiae: V. L. Eubanks, L. R. Beuchat, J. Food Prot. 46, 29 (1983). Antioxidant effectiveness: M. A. Augustin, S. K. Berry, J. Am. Oil Chem. Soc. 60, 105 (1983). Comprehensive review of biological effects and toxicology: J. Am. Coll. Toxicol. 4, 23-64 (1985).
Properties: Crystals, mp 150°. Soly at 25° in water = 0.35 g/100 ml; in alcohol = 103 g/100 g; in ether = 83 g/100 g. Soly in cottonseed oil at 30° = 1.23 g/100 g; in lard at 45° = 1.14 g/100 g. Darkens in the presence of iron and iron salts. Synergic with acids, BHA, BHT. pKa 8.11. Partition coefficient (oleyl alcohol:water) 17. Partition coefficient (octanol:water) 32. pH (0.05% aq soln) 6.3; (0.1% aq soln) 5.9; (0.2% aq soln) 5.7. LD50 in mice, rats, hamsters, rabbits (g/kg): 1.70-3.50, 2.1-7, 2.48, 2.75 orally; LD50 i.p. in rats: 0.38 g/kg (J. Am. Coll. Toxicol.).
Melting point: mp 150°
pKa: pKa 8.11
Log P: Partition coefficient (oleyl alcohol:water) 17; Partition coefficient (octanol:water) 32
Toxicity data: LD50 in mice, rats, hamsters, rabbits (g/kg): 1.70-3.50, 2.1-7, 2.48, 2.75 orally; LD50 i.p. in rats: 0.38 g/kg (J. Am. Coll. Toxicol.)
Use: Antioxidant for cosmetics, foods, fats, oils, ethers, emulsions, waxes, transformer oils.

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