Protriptyline
Title: Protriptyline
CAS Registry Number: 438-60-8
CAS Name: N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Additional Names: 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene; 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; amimetilina
Molecular Formula: C19H21N
Molecular Weight: 263.38
Percent Composition: C 86.64%, H 8.04%, N 5.32%
Literature References: Prepn: Engelhardt, Christy, BE 617967 (1962 to Merck & Co.), C.A. 59, 517f (1963); Tishler et al., US 3244748 and US 3271451 (both 1966 to Merck & Co.); Engelhardt et al., J. Med. Chem. 11, 325 (1968). Metabolism in man, pig and dog: Sisenwine et al., J. Pharmacol. Exp. Ther. 175, 51 (1970). Use in treatment of sleep apnea: R. W. Clark et al., Neurology 29, 1287 (1979); L. G. Brownell et al., N. Engl. J. Med. 307, 1037 (1982).
 
Derivative Type: Hydrochloride
CAS Registry Number: 1225-55-4
Manufacturers' Codes: MK-240
Trademarks: Concordin (Merck & Co.); Triptil (Merck & Co.); Vivactil (Merck & Co.)
Molecular Formula: C19H21N.HCl
Molecular Weight: 299.84
Percent Composition: C 76.11%, H 7.40%, N 4.67%, Cl 11.82%
Properties: Crystals from isopropanol-ethyl ether, mp 169-171°. uv max: 290 nm (e 13311). Freely sol in water. pKa 8.2.
Melting point: mp 169-171°
pKa: pKa 8.2
Absorption maximum: uv max: 290 nm (e 13311)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.

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