Pyritinol
Title: Pyritinol
CAS Registry Number: 1098-97-1
CAS Name: 3,3¢-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol]
Additional Names: bis(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl) disulfide; bis[(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)methyl] disulfide; dipyridoxolyldisulfide; pyridoxine-5-disulfide; pyrithioxin
Molecular Formula: C16H20N2O4S2
Molecular Weight: 368.47
Percent Composition: C 52.15%, H 5.47%, N 7.60%, O 17.37%, S 17.40%
Literature References: Prepn: Zima, Schorre, US 3010966 (1961 to E. Merck); Iwanami et al., Bitamin 36, 122 (1967); J. Vitaminol. 14, 321, 326 (1968). HPLC determn in urine: K. Kitao et al., Chem. Pharm. Bull. 25, 1335 (1977). Pharmacokinetics and metabolism: Darge et al., Arzneim.-Forsch. 19, 5, 9, (1969); Nowak, Schorre, ibid. 11. Clinical trial in dementia: S. Hoyer et al., ibid. 27, 671 (1977); A. J. Cooper, R. V. Magnus, Pharmacotherapeutica 2, 317 (1980); in cerebrovascular disorders: Y. Tazaki et al., J. Int. Med. Res. 8, 118 (1980).
Properties: Crystals, mp 218-220°.
Melting point: mp 218-220°
 
Derivative Type: Dihydrochloride monohydrate
Trademarks: Biocefalin (Benvegna); Bonifen (Merck KGaA); Enbol (Chugai); Encephabol (Merck KGaA); Enerbol (Polfa); Epocan (Merck KGaA); Life (SIT)
Molecular Formula: C16H20N2O4S2.2HCl.H2O
Molecular Weight: 459.41
Percent Composition: C 41.83%, H 5.27%, N 6.10%, O 17.41%, S 13.96%, Cl 15.43%
Properties: mp 184°. Note: Has no vitamin B6 activity.
Melting point: mp 184°
 
Therap-Cat: Nootropic.
Keywords: Nootropic.

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