Quin2
Title: Quin2
CAS Registry Number: 73630-23-6 (salt); 83014-44-2 (acid)
CAS Name: N-[2-[[8-[Bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)glycine tetrapotassium salt
Additional Names: 2-[[2-[bis(carboxymethyl)amino]-5-methylphenoxy]methyl]-6-methoxy-8-[bis(carboxymethyl)amino]quinoline; quin-2
Molecular Formula: C26H23K4N3O10
Molecular Weight: 693.87
Percent Composition: C 45.01%, H 3.34%, K 22.54%, N 6.06%, O 23.06%
Literature References: Fluorescent indicator dye which is primarily used for measuring changes in intracellular Ca2+. Increases in ion concn results in increased fluorescence without a shift in wavelengths. Prepn: R. Y. Tsien, Biochemistry 19, 2396 (1980). Use in measuring Ca2+ flow: J. N. Crofts, G. J. Barritt, Biochem. J. 264, 61 (1989); Zn2+-protein interactions: J. R. Jefferson et al., Anal. Biochem. 187, 328 (1990); in fluorescent lifetime imaging of cells: J. R. Lakowicz et al., Cell Calcium 15, 7 (1994). Fluorescent properties of acetoxymethyl ester: N. Miyoshi et al., Appl. Fluoresc. Technol. 4, 3 (1992). Dissociation parameters for Ca2+ and Mg2+ complexes: D. T. W. Bryant, Biochem. J. 226, 613 (1985); and photophysics: V. Van Den Bergh et al., Photochem. Photobiol. 61, 442 (1995). Review of use in measurement of Ca2+: R. Y. Tsien, T. Pozzan, Methods Enzymol. 172, 230-232 (1989).
Properties: uv max absorption (0.1M KCl): 261, 354 nm (e 37000, 5000) free dye; 240, 332 nm (e 36000, 5000) Ca2+ complex.
Absorption maximum: uv max absorption (0.1M KCl): 261, 354 nm (e 37000, 5000) free dye; 240, 332 nm (e 36000, 5000) Ca2+ complex
 
Derivative Type: Acetoxymethyl ester
CAS Registry Number: 83104-85-2
Additional Names: Quin-2AM
Molecular Formula: C38H43N3O18
Molecular Weight: 829.76
Percent Composition: C 55.00%, H 5.22%, N 5.06%, O 34.71%
 
Use: Fluorescent probe for measurement of calcium in biological systems and for selected divalent cations.

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