Raloxifene
Title: Raloxifene
CAS Registry Number: 84449-90-1
CAS Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
Additional Names: keoxifene
Manufacturers' Codes: LY-139481
Molecular Formula: C28H27NO4S
Molecular Weight: 473.58
Percent Composition: C 71.01%, H 5.75%, N 2.96%, O 13.51%, S 6.77%
Literature References: Nonsteroidal, selective estrogen receptor modulator (SERM). Prepn: C. D. Jones, EP 62503; idem, US 4418068 (1982, 1983 both to Lilly); idem et al., J. Med. Chem. 27, 1057 (1984). Review of pharmacology and toxicology: J. Buelke-Sam et al., Reprod. Toxicol. 12, 217-221 (1998); of clinical pharmacology and pharmacokinetics: D. Hochner-Celnikier, Eur. J. Obstet. Gynecol. Reprod. Biol. 85, 23-29 (1999); of clinical efficacy in osteoporosis: D. Agnusdei, ibid. 43-46. Clinical effect on risk of breast cancer: S. R. Cummings et al., J. Am. Med. Assoc. 281, 2189 (1999); on reduction of fracture risk: B. Ettinger et al., ibid. 282, 637 (1999).
Properties: Crystals from acetone, mp 143-147°. uv max (ethanol): 290 nm (e 34000).
Melting point: mp 143-147°
Absorption maximum: uv max (ethanol): 290 nm (e 34000)
 
Derivative Type: Hydrochloride
CAS Registry Number: 82640-04-8
Manufacturers' Codes: LY-156758
Trademarks: Evista (Lilly)
Molecular Formula: C28H27NO4S.HCl
Molecular Weight: 510.04
Percent Composition: C 65.94%, H 5.53%, N 2.75%, O 12.55%, S 6.29%, Cl 6.95%
Properties: Crystals from methanol/water, mp 258°. uv max (ethanol): 286 nm (e 32800).
Melting point: mp 258°
Absorption maximum: uv max (ethanol): 286 nm (e 32800)
 
Therap-Cat: Antiosteoporotic.
Keywords: Antiosteoporotic; Selective Estrogen Receptor Modulator (SERM).

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