Rociverine
Title: Rociverine
CAS Registry Number: 53716-44-2
CAS Name: 1-Hydroxy[1,1¢-bicyclohexyl]-2-carboxylic acid 2-(diethylamino)-1-methylethyl ester
Additional Names: 2-(diethylamino)-1-methylethyl cis-1-hydroxy[bicyclohexyl]-2-carboxylate
Manufacturers' Codes: LG-30158
Trademarks: Rilaten (Guidotti)
Molecular Formula: C20H37NO3
Molecular Weight: 339.51
Percent Composition: C 70.75%, H 10.98%, N 4.13%, O 14.14%
Literature References: Spasmolytic agent with balanced neurotropic and myotropic properties. Prepn: L. Turbanti, ZA 6705649 C.A. 70, 47117d (1969) and US 3700675 (1968, 1972 both to Guidotti). Antispasmodic activity in vitro and in vivo: G. Toson et al., Arzneim.-Forsch. 28, 1130 (1978). Effect in cystitis or bladder spasm: A. Manganelli, Farmaco Ed. Prat. 34, 384 (1979). Clinical studies: M. Petrillo et al., Curr. Med. Res. Opin. 7, 73 (1980); R. Assisi, S. deStefano, Acta Ther. 6, 353 (1980); F. Marsala, Minerva Med. 73, 2179 (1982).
Properties: Oil, bp0.1 148-150°. nD20 1.4820. Sol in alc, ether, chloroform, benzene, dil mineral acids. Insol in water.
Boiling point: bp0.1 148-150°
Index of refraction: nD20 1.4820
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.

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