Selenium Sulfides
Title: Selenium Sulfides
Literature References: Prepn from selenious acid and H2S; product may be a mixture of the elements: Gmelins, Selenium (8th ed.) 10 (part B), 159-176 (1949). Prepn by fusion of the elements; solid solns of sulfur (S8), selenium (Se8) and selenium sulfides (SnSe8-n; n = 1-7) formed: Fergusson et al., J. Inorg. Nucl. Chem. 24, 157 (1962); Hawes, Nature 198, 1267 (1963); Cooper, Culka, J. Inorg. Nucl. Chem. 27, 755 (1965); 29, 1217 (1967).
 
Derivative Type: Se4S4
Properties: Red tabular crystals from benzene, d 3.20. mp 113° (dec). Sol in CS2. Solubility in benzene (20°): 0.4 g/l.
Melting point: mp 113° (dec)
Density: d 3.20
 
Derivative Type: Se2S6
Properties: Light-orange needles from benzene, d 2.44. mp 121.5°. Sol in CS2. Solubility in benzene (20°): 12 g/l.
Melting point: mp 121.5°
Density: d 2.44
 
Derivative Type: Selenium disulfide
CAS Registry Number: 7488-56-4
Trademarks: Exsel (Herbert); Selsun (Abbott)
Molecular Formula: SeS2
Literature References: Prepn of shampoo: M. M. Baldwin, A. P. Young, Jr., US 2694669 (1954 to Abbott). Toxicity studies: L. M. Cummins, E. T. Kimura, Toxicol. Appl. Pharmacol. 20, 89 (1971). Review of use as antidandruff agent: Matson, J. Soc. Cosmet. Chem. 7, 459-466 (1956).
Properties: Insol in water, in 0.01N HCl. LD50 orally in rats: 138 mg/kg (Cummins, Kimura).
Toxicity data: LD50 orally in rats: 138 mg/kg (Cummins, Kimura)
 
CAUTION: Selenium sulfide (as SeS) is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-230. See also Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (PB82-164955, 1980) 113p.
Therap-Cat: Disulfide as topical antiseborrheic.
Therap-Cat-Vet: Topically in eczemas and dermatomycoses.
Keywords: Antiseborrheic.

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