Sintropium Bromide
Title: Sintropium Bromide
CAS Registry Number: 79467-19-9
CAS Name: (3-endo,8-syn)-8-Methyl-8-(1-methylethyl)-3-[(1-oxo-2-propylpentyl)oxy]-8-azoniabicyclo[3.2.1]octane bromide
Additional Names: (8r)-3a-hydroxy-8-isopropyl-1aH,5aH-tropanium bromide 2-propylvalerate; endo-8-methyl-8-syn-(1-methyl)ethyl-8-azoniabicyclo[3.2.1.]octane-3-(2-propyl)-pentanoate bromide
Manufacturers' Codes: VAL-480; VAL-4000
Molecular Formula: C19H36BrNO2
Molecular Weight: 390.40
Percent Composition: C 58.45%, H 9.29%, Br 20.47%, N 3.59%, O 8.20%
Literature References: Prepn: V. Bernareggi et al., EP 42365; eidem, US 4411902 (1981, 1983 both to Valeas). Clinical trial: M. Galeone, Minerva Med. 76, 1605 (1985); V. Colosi et al., Minerva Urol. Nefrol. 38, 271 (1986).
Properties: mp >280° (dec). LD50 i.p. in male mice: 77 mg/kg (Bernareggi).
Melting point: mp >280° (dec)
Toxicity data: LD50 i.p. in male mice: 77 mg/kg (Bernareggi)
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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