Statine
Title: Statine
CAS Registry Number: 49642-07-1
CAS Name: (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoic acid
Additional Names: AHMHA
Molecular Formula: C8H17NO3
Molecular Weight: 175.23
Percent Composition: C 54.83%, H 9.78%, N 7.99%, O 27.39%
Literature References: Amino acid present in pepstatin, q.v. Synthesis: H. Morishima et al., J. Antibiot. 26, 115 (1973). Abs config and stereospecific synthesis of all four isomers: M. Kinoshita et al., ibid. 249. Crystal structure: H. Nakamura et al., ibid. 255. Biosynthesis: H. Morishima et al., ibid. 27, 267 (1974). Alternate syntheses: M. Kinoshita et al., Bull. Chem. Soc. Jpn. 48, 570 (1975); W.-S. Liu, G. I. Glover, J. Org. Chem. 43, 754 (1978); D. H. Rich et al., ibid. 3624; K. E. Rittle et al., ibid. 47, 3016 (1982). Distribution in rats: D. A. Grant et al., Biochem. Pharmacol. 31, 2302 (1982).
Properties: mp 201-203° (dec). [a]D15 -20° (c = 0.64 in water).
Melting point: mp 201-203° (dec)
Optical Rotation: [a]D15 -20° (c = 0.64 in water)

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