Sulfoxone Sodium
Title: Sulfoxone Sodium
CAS Registry Number: 144-75-2
CAS Name: Disodium[sulfonylbis(p-phenylenimino)]dimethanesulfinate
Additional Names: 4,4¢-diaminodiphenylsulfone disodium formaldehyde sulfoxylate; disodium formaldehydesulfoxylate-diaminodiphenylsulfone; aldesulfone sodium
Trademarks: Diazon; Novotrone; Diasone (Abbott)
Molecular Formula: C14H14N2Na2O6S3
Molecular Weight: 448.45
Percent Composition: C 37.50%, H 3.15%, N 6.25%, Na 10.25%, O 21.41%, S 21.45%
Literature References: Prepn: H. Bauer, J. Am. Chem. Soc. 61, 617 (1939); S. M. Rosenthal, H. Bauer, US 2234981 (1941); G. W. Raiziss et al., J. Am. Pharm. Assoc. 33, 43 (1944); US 2256575 (1941). Therapeutic use in dermatitis herpetiformis: T. Cornbleet, Arch. Dermatol. Syphilol. 64, 684 (1951); S. I. Katz, Arch. Dermatol. 118, 809 (1982); in leprosy: J. H. Peters et al., Lepr. Rev. 46, 171 (1975). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. 19, 553-573 (1990).
 
Derivative Type: Dihydrate
Properties: Needles or amorphous powder. After drying at 100-110° it dec 263-265°. Easily sol in water. Slightly sol in alcohol. Practically insol in the usual organic solvents. Must be stored in vacuum-sealed ampuls. The addition of 10% sodium bicarbonate helps to prevent oxidative changes.
 
Therap-Cat: Antibacterial (leprostatic).
Keywords: Antibacterial (Synthetic); Sulfones; Antibacterial (Leprostatic).

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