Talbutal
Title: Talbutal
CAS Registry Number: 115-44-6
CAS Name: 5-(1-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-sec-butylbarbituric acid; 5-allyl-5-(1-methylpropyl)barbituric acid
Trademarks: Lotusate (Winthrop)
Molecular Formula: C11H16N2O3
Molecular Weight: 224.26
Percent Composition: C 58.91%, H 7.19%, N 12.49%, O 21.40%
Literature References: Prepn: Volwiler, J. Am. Chem. Soc. 47, 2236 (1925). Acute toxicity: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972).
Properties: Crystals from water or dil alcohol, mp 108-110°. Slightly bitter taste. Practically insol in water and petr ether. Sol in alcohol, chloroform, ether, acetone, glacial acetic acid, also in solns of fixed alkali hydroxides. A satd aq soln is acid to litmus. LD50 orally in rats: 57.5 mg/kg (Schafer).
Melting point: mp 108-110°
Toxicity data: LD50 orally in rats: 57.5 mg/kg (Schafer)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.13.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Barbituric Acid Derivatives.

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