Technetium 99mTc Fanolesomab
Title: Technetium 99mTc Fanolesomab
CAS Registry Number: 225239-31-6
CAS Name: Anti-(human CD15 (antigen))(mouse monoclonal RB5 m-chain)immunoglobulin M disulfide with mouse monoclonal RB5 light chain pentamer technetium-99mTc salt
Additional Names: 99mTc-anti-SSEA-1
Trademarks: LeuTech (Palatin); NeutroSpec (Palatin)
Literature References: Murine monoclonal antibody directed against stage-specific embryonic antigen-1 (SSEA-1); binds to cluster designation 15 (CD15) antigen expressed on human neutrophils. Antigranulocyte antibody designed for in vivo functional imaging and diagnosis of infection. Prepn of antibody: D. Solter, B. B. Knowles, Proc. Natl. Acad. Sci. USA 75, 5565 (1978); of labeled form: M. L. Thakur et al., J. Nucl. Med. 29, 1817 (1988). See also for diagnostic use: idem, US 4917878 (1990 to Thomas Jefferson Univ.). In vivo labeling and imaging of neutrophils: idem et al., J. Nucl. Med. 37, 1789 (1996). Clinical biodistribution and radiation dosimetry study: P. D. Mozley et al., ibid. 40, 625 (1999). Clinical evaluation as imaging agent for osteomyelitis: C. J. Palestro et al., J. Foot Ankle Surg. 42, 2 (2003); for appendicitis: E. B. Rypins et al., Ann. Surg. 235, 232 (2002). Review of development and clinical use: C. Love, C. J. Palestro, IDrugs 6, 1079-1085 (2003).
Therap-Cat: Diagnostic aid (radioactive imaging agent).
Keywords: Diagnostic Aid (Radioactive Imaging Agent).

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