Tetrandrine
Title: Tetrandrine
CAS Registry Number: 518-34-3
CAS Name: (1b)-6,6¢,7,12-Tetramethoxy-2,2¢-dimethylberbaman
Molecular Formula: C38H42N2O6
Molecular Weight: 622.75
Percent Composition: C 73.29%, H 6.80%, N 4.50%, O 15.41%
Literature References: From root of Stephania tetrandra S. Moore, Menispermaceae. Isoln: Kondo, Yano, Ann. 497, 90 (1932). Structure: Fujita, Murai, J. Pharm. Soc. Jpn. 71, 1039 (1951). Synthesis: Kataoka, C.A. 51, 16501i (1957). Total synthesis: Inubushi et al., Tetrahedron Lett. 1968, 3399; eidem, J. Chem. Soc. C 1969, 1547. Present in the Chinese drug han-fang-chi.
Properties: Needles. mp 217-218°. [a]D26 +252.4° (chloroform). Practically insol in water, petr ether; sol in ether and some other organic solvents.
Melting point: mp 217-218°
Optical Rotation: [a]D26 +252.4° (chloroform)
 
Derivative Type: l-Form
CAS Registry Number: 1263-79-2
Additional Names: Phaenthine
Properties: mp 210°. [a]D20 -278° (chloroform).
Melting point: mp 210°
Optical Rotation: [a]D20 -278° (chloroform)
 
Therap-Cat: Analgesic; antipyretic.
Keywords: Analgesic (Non-Narcotic); Antipyretic.

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